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Tag: IBS-D

American Gastroenterological Association Institute Guideline on the Pharmacological Management of Irritable Bowel Syndrome

This 2014 guideline by the American Gastroenterological Association (AGA) provides evidence-based recommendations for the pharmacological treatment of irritable bowel syndrome (IBS) in adults. Utilizing the GRADE methodology, the guideline evaluates various medications for IBS subtypes. For IBS with constipation (IBS-C), it recommends linaclotide and lubiprostone. For IBS with diarrhea (IBS-D),

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June 26, 2025 No Comments

Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome

The 2016 observational study titled “Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome” (PMID: 25972430) examined the effect of glutamine on tight junction protein expression in IBS-D patients. Using colonic biopsy specimens from 12 patients, researchers incubated tissues with glutamine at

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June 26, 2025 No Comments

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome

This randomized, double-blind, placebo-controlled trial titled “Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome” (PMID: 30108163), published in Gut, evaluated the efficacy of oral glutamine in patients with postinfectious diarrhea-predominant irritable bowel syndrome (IBS-D) and increased intestinal permeability. The study demonstrated that glutamine supplementation significantly improved

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June 26, 2025 No Comments