hs-CRP Archives - Well Referenced

Effect of Monacolin K and CoQ10 Supplementation in Hypertensive and Hypercholesterolemic Subjects with Metabolic Syndrome

This study evaluated the effects of a combined supplementation of Monacolin K (10 mg/day) and Coenzyme Q10 (30 mg/day) over 8 weeks in 40 patients with metabolic syndrome characterized by hypertension and hypercholesterolemia. The intervention led to significant reductions in systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, and

June 26, 2025 No Comments

Effects of Alpha-Lipoic Acid Supplementation on Inflammatory Biomarkers and Matrix Metalloproteinase-3 in Rheumatoid Arthritis Patients

This 2015 randomized, double-blind, placebo-controlled clinical trial evaluated the effects of 8-week supplementation with 1200 mg/day alpha-lipoic acid (ALA) on inflammatory biomarkers and matrix metalloproteinase-3 (MMP-3) in 70 women with rheumatoid arthritis (RA). Participants were assessed for serum levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6),

June 26, 2025 No Comments

Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis

This 2019 prospective cohort study published in JAMA Network Open (PMID: 31390038) analyzed long-term immune response trajectories in 483 sepsis survivors across 12 U.S. hospitals. Researchers tracked biomarkers of inflammation (hs-CRP) and immunosuppression (sPD-L1) over 12 months and identified two phenotypes: one with persistent hyperinflammation and immunosuppression, and another with

June 26, 2025 No Comments

Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association

This 2003 practice guideline published in Circulation (DOI: 10.1161/01.cir.0000052939.59093.45) by the CDC and AHA evaluates the clinical relevance of inflammatory markers, particularly high-sensitivity C-reactive protein (hs-CRP), in assessing cardiovascular disease (CVD) risk. It concludes that hs-CRP is a useful tool for identifying low-grade systemic inflammation and may enhance cardiovascular risk

June 26, 2025 No Comments

Obesity, dyslipidemia, and high blood pressure are associated with cardiovascular risk, determined using high-sensitivity C-reactive protein concentration, in young adults

This 2020 observational study published in the Journal of International Medical Research (PMID: 33342336) analyzed 300 young adults in southern Mexico to examine the relationship between high-sensitivity C-reactive protein (hs-CRP) and cardiometabolic risk factors. It found that elevated hs-CRP (>28.57 nmol/L) was strongly associated with obesity (OR = 13.9), high

June 26, 2025 No Comments

Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis

This cohort study published in PLoS One examines the association between blood inflammatory markers (such as hs-CRP, IL-6, and others) and mortality in older adults using data from the Health and Retirement Study (HRS). The study found that higher levels of inflammatory markers were significantly linked to increased mortality risk,

June 26, 2025 No Comments

Cumulative Exposure to High-Sensitivity C-Reactive Protein Predicts the Risk of Cardiovascular Disease

This large cohort study in a Chinese adult population examined the impact of cumulative exposure to high-sensitivity C-reactive protein (hs-CRP) on cardiovascular disease (CVD) risk, demonstrating a 38% higher risk of CVD and over a two-fold increase in myocardial infarction risk for those with consistently elevated hs-CRP levels across multiple

June 26, 2025 No Comments

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