Well Referenced

Tag: hormone receptor-positive

Effectiveness of Adding Everolimus to the First-line Treatment of Advanced Breast Cancer in Premenopausal Women Who Experienced Disease Progression While Receiving Selective Estrogen Receptor Modulators: A Phase 2 Randomized Clinical Trial

This 2021 phase 2 randomized clinical trial (MIRACLE study) assessed the benefit of adding everolimus to letrozole in premenopausal women with hormone receptor-positive, ERBB2-negative advanced breast cancer who had progressed on selective estrogen receptor modulators (SERMs). A total of 199 patients were randomized to receive either everolimus (10 mg/day) with

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June 26, 2025 No Comments

Testosterone and breast cancer prevention

This review discusses emerging evidence supporting the role of testosterone (T), alone or in combination with the aromatase inhibitor anastrozole (T+A), in reducing the incidence of breast cancer and possibly treating existing hormone receptor-positive tumors. Subcutaneous T or T+A implants have demonstrated symptom relief in women with androgen deficiency, including

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June 26, 2025 No Comments