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Tag: HMG-CoA reductase inhibitors

Molecular Targets of Statins and Their Potential Side Effects: Not All the Glitter Is Gold

This 2022 review explores the multifaceted molecular actions of statins beyond their primary role in lowering LDL cholesterol. While statins are effective in reducing cardiovascular events, they also exhibit pleiotropic effects, including anti-inflammatory and antitumor activities. However, these benefits are accompanied by potential adverse effects such as myopathy, new-onset type

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June 26, 2025 No Comments

Statins in Risk-Reduction and Treatment of Cancer

This 2020 review article explores the growing body of evidence supporting the use of statins in both cancer prevention and treatment. Statins, through inhibition of the HMG-CoA reductase pathway, exhibit antiproliferative, pro-apoptotic, anti-angiogenic, and immunomodulatory effects in multiple cancer types such as breast, prostate, lung, colorectal, and ovarian cancers. Their

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June 26, 2025 No Comments

Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study

This retrospective cohort study analyzed data from 46,864 individuals aged 75 and older without clinically recognized atherosclerotic cardiovascular disease (CVD) to evaluate the impact of statin therapy on primary prevention. Over a median follow-up of 5.6 years, statin use did not significantly reduce CVD events or all-cause mortality in those

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June 26, 2025 No Comments

Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study

This observational study examined how statins influence the progression of coronary artery calcium (CAC) scores and coronary plaque volume in patients with coronary artery disease. The results indicated that statin therapy slowed the progression of both CAC and plaque volume, with the degree of effect varying by statin type. The

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June 26, 2025 No Comments