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Tag: histone acetylation

Lunasin sensitivity in non-small cell lung cancer cells is linked to suppression of integrin signaling and changes in histone acetylation

This 2014 study investigates the differential sensitivity of non-small cell lung cancer (NSCLC) cell lines to lunasin, a soy-derived peptide with anticancer properties. The research compares lunasin-sensitive H661 cells to resistant H1299 cells, revealing that lunasin internalization is higher in H661 cells. Lunasin interacts with integrins containing αv, α5, β1,

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June 26, 2025 No Comments

Lunasin: a cancer-preventive soy peptide

This 2005 review highlights lunasin, a 43-amino-acid peptide derived from soy, as a promising agent in cancer prevention. Lunasin demonstrates efficacy against chemical carcinogens and oncogenes in mammalian cells and a skin cancer mouse model. It internalizes into mammalian cells within minutes and localizes in the nucleus after 18 hours,

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June 26, 2025 No Comments

Complementary roles in cancer prevention: protease inhibitor makes the cancer preventive peptide lunasin bioavailable

This study examines the role of the Bowman-Birk protease inhibitor (BBI) in enhancing the oral bioavailability and cancer-preventive activity of lunasin, a soy-derived peptide known for its epigenetic modulation properties. Lunasin binds to deacetylated histones and inhibits histone acetylation, thereby regulating gene expression involved in tumorigenesis. However, its effectiveness is

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June 26, 2025 No Comments