Well Referenced

Tag: heterotopic ossification

Contemporary perspectives on heterotopic ossification

This 2022 review explores the mechanisms and management of heterotopic ossification (HO), distinguishing between trauma-induced (tHO) and genetic forms like fibrodysplasia ossificans progressiva (FOP). The study highlights that both forms involve reactivation of developmental bone pathways, including intramembranous and endochondral ossification. Current prophylactic treatments include NSAIDs for tHO and glucocorticoids

Read More »
June 26, 2025 No Comments

Heterotopic Ossification: A Comprehensive Review

This 2019 comprehensive review discusses heterotopic ossification (HO), the pathological formation of bone in soft tissues. HO is often triggered by trauma, surgery, burns, or neurological injuries. The review covers clinical features, radiographic and histopathologic diagnosis, and treatment options, including NSAIDs, radiation therapy, and surgical excision. It also explores the

Read More »
June 26, 2025 No Comments

Prevention of heterotopic ossification after total hip replacement: a prospective comparison of indomethacin and salmon calcitonin in 60 patients

This 2001 prospective study compared the efficacy of indomethacin (100 mg/day) and salmon calcitonin (3 MRC-U/kg/day) administered for 14 days in preventing heterotopic ossification (HO) following total hip replacement. Among 60 patients (30 per group), 19 in the indomethacin group and 2 in the calcitonin group developed HO. The findings

Read More »
June 26, 2025 No Comments