Hedgehog pathway Archives - Well Referenced

Cancer Stem Cells: Role in Tumor Growth, Recurrence, Metastasis, and Treatment Resistance

This article provides an overview of cancer stem cells (CSCs) and their pivotal role in tumor biology. CSCs are a subset of tumor cells with self-renewal and differentiation capabilities, contributing to tumor initiation, growth, metastasis, and recurrence. They exhibit resistance to conventional therapies, including chemotherapy and radiotherapy, due to factors

June 26, 2025 No Comments

Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers

This 2023 review highlights the therapeutic potential of mebendazole (MBZ), a benzimidazole antiparasitic agent, as a repurposed drug for brain cancers, particularly glioblastoma and medulloblastoma. MBZ exerts anti-cancer effects by disrupting microtubule polymerization, inhibiting angiogenesis, inducing apoptosis, and modulating key oncogenic pathways such as Hedgehog signaling. Preclinical models demonstrate MBZ’s

June 26, 2025 No Comments

Tag: Hedgehog pathway

Cancer Stem Cells: Role in Tumor Growth, Recurrence, Metastasis, and Treatment Resistance

Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers