Tag: Hedgehog inhibition

This 2015 ReDO project review highlights itraconazole’s potential as a repurposed anticancer agent. Itraconazole, a triazole antifungal, exhibits mechanisms relevant to oncology including inhibition of angiogenesis, suppression of the Hedgehog signaling pathway, and induction of autophagic growth arrest. Preclinical and clinical evidence supports its efficacy in prostate, non-small cell lung,