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Tag: heavy metal detoxification

Chelation Therapy in Patients With Cardiovascular Disease: A Systematic Review

This systematic review evaluated the efficacy of ethylenediaminetetraacetic acid (EDTA) chelation therapy in patients with pre-existing cardiovascular disease (CVD). Analyzing 24 studies—including 4 randomized clinical trials, 15 prospective before/after studies, and 5 retrospective case series—the review found that 17 studies reported improved outcomes following EDTA treatment. Notably, the most significant

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June 26, 2025 No Comments

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review

This review article explores the mechanisms by which cadmium (Cd) induces oxidative stress and evaluates the potential protective roles of natural antioxidants. Cd exposure disrupts cellular redox homeostasis through the excessive generation of reactive oxygen species (ROS), leading to damage in lipids, proteins, and DNA. The review highlights natural antioxidant

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June 26, 2025 No Comments

Toxic Metals and Antioxidants: Part II. The Role of Antioxidants in Arsenic and Cadmium Toxicity

This comprehensive review explores the mechanisms by which arsenic and cadmium exert toxic effects, primarily through oxidative stress and interference with essential metal ions. The article highlights the role of antioxidants and thiol-containing compounds in mitigating these toxicities. Key antioxidants discussed include S-adenosylmethionine, lipoic acid, glutathione, selenium, zinc, N-acetylcysteine (NAC),

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June 26, 2025 No Comments

Chelation: harnessing and enhancing heavy metal detoxification–a review

This 2013 review by Margaret E. Sears examines the role of chelation in detoxifying heavy metals such as arsenic, cadmium, lead, and mercury, which are prevalent environmental toxins contributing to chronic diseases. The paper discusses both natural chelators like glutathione and metallothionein, and pharmaceutical agents such as EDTA, DMSA, and

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June 26, 2025 No Comments

Chelation Therapy for Ischemic Heart Disease: A Randomized Controlled Trial

This multicenter randomized controlled trial investigated the effectiveness of disodium EDTA chelation therapy in patients with a history of myocardial infarction. Participants were randomized to receive either EDTA-based chelation therapy or placebo over a series of infusions. The primary composite endpoint included all-cause mortality, recurrent myocardial infarction, stroke, coronary revascularization,

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June 26, 2025 No Comments

The effect of modified citrus pectin on urinary excretion of toxic elements

This pilot study investigated the effect of modified citrus pectin (MCP) on the urinary excretion of toxic metals in healthy individuals. Participants taking MCP for 5-6 days experienced significant increases in the excretion of arsenic (130%), cadmium (150%), and lead (560%) via urine, suggesting MCP’s potential to aid in detoxification

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June 26, 2025 No Comments

β-Lactoglobulin Enhances Clay and Activated Carbon Binding and Protection Properties for Cadmium and Lead

This 2024 in vitro study explored the use of β-lactoglobulin, a whey protein, to enhance the heavy metal-binding capabilities of clay and activated carbon for detoxifying cadmium and lead. Researchers found that combining β-lactoglobulin with these adsorbents significantly increased their binding capacity, likely due to the protein’s chelating properties, which

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June 26, 2025 No Comments

Mercury binding to the chelation therapy agents DMSA and DMPS and the rational design of custom chelators for mercury

This study investigates the efficacy of two commonly used chelation therapy agents, meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercaptopropane-1-sulfonic acid (DMPS), in binding mercuric ions (Hg²⁺). Using mercury L(III)-edge X-ray absorption spectroscopy and density functional theory calculations, researchers found that neither DMSA nor DMPS forms true chelate complexes with Hg²⁺, which may

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June 26, 2025 No Comments

The administration of N-acetylcysteine reduces oxidative stress and regulates glutathione metabolism in the blood cells of workers exposed to lead

This randomized controlled trial investigated the effects of N-acetylcysteine (NAC) supplementation on oxidative stress and glutathione metabolism in 171 lead-exposed male workers. Participants were divided into four groups: a control group and three groups receiving NAC at doses of 200 mg, 400 mg, or 800 mg per day for 12

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June 26, 2025 No Comments