Well Referenced

Tag: healthspan

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

This 2021 study published in Nature Communications investigated the role of MOTS-c, a mitochondrial-derived peptide, in regulating age-related physical decline and muscle homeostasis. The researchers found that MOTS-c levels significantly increased in human skeletal muscle and plasma following exercise. In mouse models, both young and aged mice treated with MOTS-c

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June 26, 2025 No Comments

Of Mice and Men: The Benefits of Caloric Restriction, Exercise, and Mimetics

This review explores the physiological and molecular effects of caloric restriction (CR), exercise, and pharmacological mimetics on aging and metabolic health. CR has been shown to extend both mean and maximum lifespan in animal models by activating stress response pathways and enhancing mitochondrial function. Exercise primarily improves healthspan, delaying the

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June 26, 2025 No Comments

Taurine deficiency as a driver of aging

This 2023 study published in Science investigated the role of taurine, a semi-essential amino acid, in the aging process. Researchers observed that taurine levels decline with age in mice, monkeys, and humans. Supplementation of taurine in middle-aged mice increased lifespan by 10–12% and improved healthspan in monkeys. Mechanistically, taurine supplementation

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June 26, 2025 No Comments

NAD+ in Aging: Molecular Mechanisms and Translational Implications

This 2017 review explores the critical role of nicotinamide adenine dinucleotide (NAD⁺) in aging and age-related diseases. NAD⁺ is essential for cellular metabolism, DNA repair, and stress responses. The study highlights that NAD⁺ levels decline with age, contributing to various pathologies, including neurodegenerative diseases, cardiovascular conditions, and muscle atrophy. The

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June 26, 2025 No Comments

Metformin: A Hopeful Promise in Aging Research

This 2016 review highlights metformin’s potential as a geroprotective agent beyond its established use in type 2 diabetes management. The authors discuss metformin’s mechanisms, including activation of AMPK, inhibition of mTOR signaling, reduction of oxidative stress, and modulation of inflammatory responses. These actions collectively contribute to improved metabolic health and

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June 26, 2025 No Comments

Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives

This 2017 review discusses the integration of geroprotective interventions, such as calorie restriction mimetics, autophagy inducers, and senolytics, into public health strategies. It highlights the potential of these interventions to extend healthspan and delay age-related diseases. The authors address challenges including regulatory hurdles, ethical considerations, and the need for robust

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June 26, 2025 No Comments

Modern Biological Theories of Aging

This 2010 review by Kunlin Jin provides a comprehensive overview of current biological theories explaining the aging process, categorizing them into two broad groups: programmed theories and damage (or error) theories. Programmed theories suggest that aging is regulated by genetically controlled processes, including hormonal changes, immune decline, and epigenetic modifications.

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June 26, 2025 No Comments

Are Menopause, Aging and Prostate Cancer Diseases?

This 2023 article by Mikhail V. Blagosklonny explores the classification of menopause, aging, and prostate cancer as diseases through the lens of the hyperfunction theory of aging. While prostate cancer is universally recognized as a disease, the author argues that menopause, despite being a natural process, is also a disease

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June 26, 2025 No Comments

Metformin as a Tool to Target Aging

This review explores metformin’s potential as an anti-aging therapy, highlighting its modulation of key aging-related pathways such as AMPK activation, mTOR inhibition, and IGF-1 signaling reduction. Preclinical studies demonstrate metformin’s ability to extend lifespan and healthspan in various organisms. Observational data suggest reduced incidence of age-related diseases in metformin users.

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June 26, 2025 No Comments

Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging Targets

This 2021 in vitro/animal study published in Biomolecules (DOI: 10.3390/biom12010039) used a multi-omics approach to identify novel biomarkers and potential therapeutic targets associated with aging. The researchers uncovered key molecular and metabolic changes that occur with aging, highlighting pathways and proteins that could serve as future diagnostic tools or intervention

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June 26, 2025 No Comments