This 2007 review examines the metabolic impacts of high-protein diets, particularly in weight-stable individuals. Findings indicate that higher protein intake is associated with lower blood pressure and, in diabetic patients, reduced glycosylated hemoglobin levels. However, the long-term effects on atherosclerosis risk remain unclear due to limited and conflicting epidemiological data.
This randomized trial evaluated the effects of low-carbohydrate and low-fat diets on weight and metabolic outcomes over two years in overweight and obese adults. Participants were assigned to either a low-carbohydrate diet (starting at 20 g/day of carbohydrates, gradually increasing) or a low-fat diet (1200–1800 kcal/day with ≤30% of calories
The study evaluated the efficacy of evacetrapib, a CETP inhibitor, in reducing major adverse cardiovascular events (MACE) despite its ability to significantly raise HDL cholesterol by 130% and lower LDL cholesterol by 37%. Conducted on over 12,000 high-risk cardiovascular patients, the trial was halted early due to a lack of
This study from the Women’s Health Initiative Observational Study examined how postmenopausal hormone therapy (PHT) affects biomarkers associated with coronary heart disease (CHD). Results showed that PHT use is linked to increased CRP, HDL, and triglyceride levels, as well as lower tPA-antigen and homocysteine. Estrogen plus progestin use was associated
