This review article explores the role of histamine as a central neurotransmitter in regulating appetite and metabolism. Histamine exerts anorexigenic effects primarily through H₁ receptor stimulation, mediating leptin’s inhibitory impact on appetite and potentially delaying leptin resistance in high-fat diet-induced obesity. Additionally, histamine may enhance lipolysis, contributing to weight regulation.
This review article examines the role of the histaminergic system in regulating feeding behavior and taste perception. Histamine acts as an anorectic neurotransmitter via H₁ receptor stimulation and is positioned downstream of leptin signaling. The study highlights that histaminergic activity increases during feeding and is influenced by oral somatic sensations
This 2011 review by Teff and Kim explores how atypical antipsychotics (AAPs) influence central and peripheral mechanisms regulating appetite and metabolism. AAPs, notably clozapine and olanzapine, are associated with significant weight gain and metabolic disturbances. The authors discuss how these drugs affect hypothalamic pathways, particularly through antagonism of histamine H1
