Well Referenced

Tag: gut barrier function

Noninvasive biomarkers of gut barrier function identify two subtypes of patients suffering from diarrhoea predominant-IBS: a case-control study

This 2018 case-control study published in BMC Gastroenterology (PMID: 30400824) investigated gut permeability and inflammation in patients with diarrhoea-predominant irritable bowel syndrome (D-IBS), identifying two subtypes based on intestinal barrier function. Among 39 D-IBS patients, 46.2% exhibited increased small-intestinal permeability as measured by lactulose/mannitol ratio, along with elevated levels of

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June 26, 2025 No Comments

Glutamine and the regulation of intestinal permeability: from bench to bedside

The 2017 review article “Glutamine and the Regulation of Intestinal Permeability: From Bench to Bedside” (PMID: 27749689) highlights glutamine’s essential role in preserving and regulating intestinal barrier function. The review outlines how glutamine supports enterocyte proliferation, modulates tight junction protein expression, and protects mucosal integrity. It draws on both animal

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June 26, 2025 No Comments

Glutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats

The 2014 study titled “Glutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats” (DOI: 10.1016/j.clnu.2013.09.003) examined the effects of glutamine and combined glutamine-arginine supplementation on gut barrier integrity during chemotherapy-induced intestinal mucositis. The study found that glutamine supplementation significantly improved

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June 26, 2025 No Comments

Review: A systematic review of the effects of functional amino acids on small intestine barrier function and immunity in piglets

This systematic review evaluates the effects of functional amino acids—specifically L-Arginine, L-Glutamine, and L-Glutamate—on gut barrier function and immune health in post-weaning piglets. The findings suggest that supplementing these amino acids beyond standard nutritional requirements enhances gut morphology, tight junction integrity, and immune response, especially during the stressful weaning period.

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June 26, 2025 No Comments

Associations among gut permeability, inflammatory markers, and symptoms in patients with irritable bowel syndrome

This 2014 observational study published in Journal of Gastroenterology (PMID: 24435814) examined links between gut permeability, immune markers, and symptom severity in patients with irritable bowel syndrome (IBS). Using lactulose/mannitol (L/M) ratios to assess permeability and IL-10 levels to gauge immune response, the study identified a subgroup of IBS patients

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June 26, 2025 No Comments

Biomarkers for assessment of intestinal permeability in clinical practice

This 2021 observational study published in American Journal of Physiology-Gastrointestinal and Liver Physiology (PMID: 34009040) evaluated the correlation between the traditional lactulose/mannitol (L/M) test for intestinal permeability and surrogate biomarkers such as plasma lipopolysaccharide-binding protein (LBP) and fecal zonulin. In two cohorts—51 healthy individuals and 27 with obesity—the study found

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June 26, 2025 No Comments

Development and Validation of Test for “Leaky Gut” Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults

This 2021 randomized controlled trial published in Gastroenterology (PMID: 33865841) evaluated the accuracy and reproducibility of sugar probe testing to assess intestinal permeability in healthy adults and IBS-D patients. Researchers found that ^13C-mannitol, unlike ^12C-mannitol, served as a reliable marker for small intestinal permeability, with consistent results unaffected by age,

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June 26, 2025 No Comments

Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome

This 2009 observational study published in Pain (PMID: 19595511) explored the relationship between intestinal permeability and pain sensitivity in patients with diarrhea-predominant irritable bowel syndrome (D-IBS). Among 54 D-IBS patients and 22 healthy controls, 39% of D-IBS patients had increased intestinal permeability, as indicated by elevated lactulose/mannitol ratios. These individuals

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June 26, 2025 No Comments