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Tag: GHRH antagonists

Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis

This review explores the role of growth hormone-releasing hormone (GHRH) and its analogues in enhancing mesenchymal stromal cell (MSC)-mediated angiogenesis and tissue repair. GHRH analogues activate the STAT3 signaling pathway in MSCs, promoting angiogenesis and regenerative processes, while GHRH antagonists inhibit these pathways and may serve as potential antitumor agents.

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June 26, 2025 No Comments

Growth hormone-releasing hormone in endothelial inflammation

This review examines the potential therapeutic effects of growth hormone-releasing hormone (GHRH) antagonists in protecting against endothelial barrier dysfunction, particularly in conditions like sepsis and acute respiratory distress syndrome. Preclinical studies suggest that GHRH antagonists could improve vascular function and reduce inflammation, making them promising candidates for treating vascular-related pathologies.

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June 26, 2025 No Comments

Growth hormone-releasing hormone receptor (GHRH-R) and its role in cardiac repair

This review article explores the structure, signaling pathways, and therapeutic potential of the growth hormone-releasing hormone receptor (GHRH-R) and its splice variants (SVs). GHRH-R is primarily expressed in the pituitary gland, and its activation triggers growth hormone secretion through cAMP-dependent pathways. The review also highlights the role of GHRH analogs

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June 26, 2025 No Comments

The development of growth hormone-releasing hormone analogs: Therapeutic advances in cancer, regenerative medicine, and metabolic disorders

This review examines the therapeutic potential of growth hormone-releasing hormone (GHRH) analogs, including both agonists and antagonists, in various medical fields such as oncology, regenerative medicine, and metabolic disorders. GHRH agonists have shown promise in promoting tissue regeneration, improving cardiac function, and enhancing islet survival in diabetes, while GHRH antagonists

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June 26, 2025 No Comments

Antagonists of growth-hormone-releasing hormone: an emerging therapy for tumors

This review article discusses the potential use of growth-hormone-releasing hormone (GHRH) antagonists in cancer therapy. GHRH antagonists have been shown to inhibit the growth of various human cancer lines, including breast, ovarian, prostate, lung, brain, and other cancers, in xenograft models. The therapeutic action is primarily through blocking the autocrine/paracrine

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June 26, 2025 No Comments