This 2010 article by Mikhail V. Blagosklonny proposes a translational framework to extend healthy lifespan by pharmacologically suppressing aging. The author introduces the concept of “post-aging syndrome,” where age-related diseases are delayed or prevented through targeted interventions. Central to this approach is the inhibition of the mTOR pathway, which is
This 2017 review discusses the integration of geroprotective interventions, such as calorie restriction mimetics, autophagy inducers, and senolytics, into public health strategies. It highlights the potential of these interventions to extend healthspan and delay age-related diseases. The authors address challenges including regulatory hurdles, ethical considerations, and the need for robust
This 2023 article by Mikhail V. Blagosklonny explores the classification of menopause, aging, and prostate cancer as diseases through the lens of the hyperfunction theory of aging. While prostate cancer is universally recognized as a disease, the author argues that menopause, despite being a natural process, is also a disease
