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Tag: genomic instability

Hallmarks of aging: An expanding universe

This 2023 review expands the original 2013 framework of nine hallmarks of aging to twelve, reflecting advances in aging research. The updated hallmarks are: (1) genomic instability, (2) telomere attrition, (3) epigenetic alterations, (4) loss of proteostasis, (5) disabled macroautophagy, (6) deregulated nutrient sensing, (7) mitochondrial dysfunction, (8) cellular senescence,

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June 26, 2025 No Comments

Erectile response to vardenafil in men with a history of nonresponse to sildenafil: a time-from-dosing descriptive analysis

This observational study examined the presence of jumping translocations involving the long arms of chromosome 1 in patients with myeloid malignancies. These chromosomal rearrangements, characterized by the translocation of chromosome 1q segments to different recipient chromosomes within the same individual, contribute to genomic instability and are associated with an increased

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June 26, 2025 No Comments