Well Referenced

Tag: gastrointestinal health

The use of probiotics in healthy volunteers with evacuation disorders and hard stools: a double-blind, randomized, placebo-controlled study

This double-blind, randomized, placebo-controlled study assessed the efficacy of two probiotic blends in managing evacuation disorders and hard stools among 300 healthy volunteers aged 24–71 years. Participants were divided into three groups: Group A received a placebo; Group B received a combination of Lactobacillus plantarum LP01 and Bifidobacterium breve BR03

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June 26, 2025 No Comments

Stable Gastric Pentadecapeptide BPC 157-NO-System Relation

This review explores the interaction between BPC 157, a stable gastric pentadecapeptide, and the nitric oxide (NO) system. BPC 157 modulates NO pathways, counteracting both NO synthase inhibition (e.g., L-NAME-induced hypertension) and overactivation (e.g., L-arginine-induced hypotension). It promotes vascular integrity, reduces thrombosis and bleeding, and enhances healing across various tissues.

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June 26, 2025 No Comments

Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect

This preclinical study examined the therapeutic effects of BPC 157, a stable gastric pentadecapeptide, in a rat model of stomach perforation-induced general occlusion syndrome. Researchers observed that BPC 157 administration mitigated systemic complications such as vascular and multiorgan failure, thrombosis, and hemorrhage. The peptide facilitated rapid healing of the gastric

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June 26, 2025 No Comments

Stress in Gastrointestinal Tract and Stable Gastric Pentadecapeptide BPC 157. Finally, do we have a Solution?

This comprehensive review explores the therapeutic potential of BPC 157, a stable gastric pentadecapeptide, in addressing various gastrointestinal (GI) disorders and stress-induced injuries. BPC 157 exhibits cytoprotective, anti-inflammatory, and angiogenic properties, facilitating healing in conditions like ulcers, esophagitis, and inflammatory bowel disease. Preclinical studies demonstrate its efficacy in promoting mucosal

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June 26, 2025 No Comments

Stable Gastric Pentadecapeptide BPC 157 and Wound Healing

This comprehensive review evaluates the therapeutic potential of BPC 157, a stable gastric pentadecapeptide, in promoting wound healing across various tissue types. Preclinical studies have demonstrated BPC 157’s efficacy in accelerating the healing of skin wounds, including incisional and excisional injuries, deep burns, diabetic ulcers, and alkali burns. The peptide

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June 26, 2025 No Comments

Stable Gastric Pentadecapeptide BPC 157 Heals Rat Colovesical Fistula

This preclinical study evaluated the therapeutic effects of BPC 157, a stable gastric pentadecapeptide, on healing colovesical fistulas in rats. Wistar Albino male rats with surgically induced colovesical fistulas were treated with BPC 157 administered either intraperitoneally or orally. The treatment led to accelerated fistula closure, reduced inflammation, and improved

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June 26, 2025 No Comments

Stable Gastric Pentadecapeptide BPC 157 in the Treatment of Colitis and Ischemia and Reperfusion in Rats: New Insights

This preclinical study investigated the therapeutic effects of BPC 157, a stable gastric pentadecapeptide, in rat models of colitis and ischemia-reperfusion injury. BPC 157 administration led to significant improvements in mucosal healing, reduction of inflammatory markers, and restoration of vascular integrity. The peptide modulated the nitric oxide (NO) system, counteracting

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June 26, 2025 No Comments

Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and Distended Stomach, and Vascular Response

This review article explores the therapeutic potential of BPC 157, a stable gastric pentadecapeptide, in treating gastrointestinal disorders, particularly inflammatory bowel disease (IBD). Clinical trials (PL-10, PLD-116, PL 14736) have demonstrated its safety profile. BPC 157 exhibits cytoprotective and adaptive cytoprotective activities, promoting healing in various gastrointestinal lesions. In animal

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June 26, 2025 No Comments

Stable Gastric Pentadecapeptide BPC 157 May Recover Brain-Gut Axis and Gut-Brain Axis Function

This comprehensive review examines the therapeutic potential of BPC 157, a stable gastric pentadecapeptide, in restoring the brain-gut and gut-brain axes. BPC 157 exhibits cytoprotective, anti-inflammatory, and angiogenic properties, facilitating healing in various tissues. Preclinical studies demonstrate its efficacy in promoting mucosal integrity, enhancing nitric oxide pathways, and modulating the

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June 26, 2025 No Comments