Well Referenced

Tag: GABA

Bodyweight gain and anticonvulsants: a comparative review

This 2001 review by Jallon and Picard examines the prevalence, mechanisms, and clinical implications of weight gain associated with anticonvulsant therapy. The authors highlight that medications such as valproic acid, carbamazepine, vigabatrin, and gabapentin are frequently linked to significant weight gain in patients with epilepsy, affecting both pediatric and adult

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June 26, 2025 No Comments

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

This 2014 study investigates how acetate, a short-chain fatty acid produced by gut microbial fermentation of dietary fiber, influences appetite regulation. Using in vivo imaging and metabolic tracing in mice, researchers demonstrated that acetate crosses the blood-brain barrier and accumulates in the hypothalamus. There, it enhances glutamate–glutamine and GABA neurotransmitter

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June 26, 2025 No Comments