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Tag: G2/M Arrest

Protoapigenone, a Novel Flavonoid, Inhibits Ovarian Cancer Cell Growth In Vitro and In Vivo

This 2008 study evaluates the anticancer potential of protoapigenone, a naturally occurring flavonoid isolated from fern species, in ovarian cancer models. In vitro, protoapigenone suppressed proliferation and colony formation of ovarian cancer cell lines (MDAH-2774 and SKOV3) by inducing apoptosis and G2/M cell cycle arrest. Mechanistically, it activated stress signaling

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June 26, 2025 No Comments

Repurposing the Anti-Malarial Drug Artesunate as a Novel Therapeutic Agent for Metastatic Renal Cell Carcinoma Due to Its Attenuation of Tumor Growth, Metastasis, and Angiogenesis

This 2015 study explores the potential of artesunate (ART), an anti-malarial drug, as a treatment for metastatic renal cell carcinoma (RCC). Analysis of patient data revealed that high expression of transferrin receptor 1 (TfR1), a marker associated with ART sensitivity, correlated with distant metastasis and poor prognosis in clear cell

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June 26, 2025 No Comments

Deglucohellebrin: A Potent Agent for Glioblastoma Treatment

This 2019 study investigates the anti-glioma effects of deglucohellebrin (DGH), a compound extracted from the roots of Helleborus odorus subsp. cyclophyllus. DGH demonstrated significant cytotoxicity against glioblastoma cell lines U251MG, T98G (notably resistant to temozolomide), and U87G, with IC50 values of 7×10⁻⁵ M, 5×10⁻⁵ M, and 4×10⁻⁵ M, respectively, over

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June 26, 2025 No Comments