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Tag: Free testosterone

A clinical update on female androgen insufficiency–testosterone testing and treatment in women presenting with low sexual desire

This 2006 review discusses female androgen deficiency syndrome (FADS), characterized by diminished well-being, unexplained fatigue, and decreased sexual desire in estrogen-replete women. Diagnosis is supported by low free testosterone levels, though measurement challenges exist due to assay limitations. Causes include hypopituitarism, adrenal and ovarian insufficiency, glucocorticoid therapy, and age-related decline.

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June 26, 2025 No Comments

Serum testosterone and the risk of prostate cancer: potential implications for testosterone therapy

This case-control study examined the association between serum testosterone levels and prostate cancer risk, highlighting potential implications for testosterone therapy. Analyzing 794 male participants from the Baltimore Longitudinal Study of Aging, researchers found that men with higher free testosterone levels had a significantly increased risk of prostate cancer (RR 2.59,

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June 26, 2025 No Comments

Measurement of free testosterone in normal women and women with androgen deficiency: comparison of methods

This study compared different methods for measuring free testosterone in women, focusing on the accuracy and reliability of equilibrium dialysis, direct radioimmunoassay (RIA), and calculated values using the law of mass action. The results showed that calculated free testosterone values correlated excellently with equilibrium dialysis, making these methods more reliable

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June 26, 2025 No Comments

A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications

This article reviews the binding of testosterone to circulating proteins, focusing on its role in androgen disorders and its implications for clinical management, including testosterone replacement therapy. It highlights the importance of distinguishing between free and bound testosterone for accurate diagnosis and treatment. The review stresses that only free testosterone

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June 26, 2025 No Comments