This 2015 study by Schöttker et al. investigates the association between oxidative stress biomarkers and all-cause mortality in older adults. In a German cohort of 2,932 participants with a median age of 70, researchers measured derivatives of reactive oxygen metabolites (d-ROMs) and total thiol levels (TTL) as proxies for oxidative
This 2015 meta-analysis conducted by the CHANCES consortium analyzed data from over 10,000 individuals aged 45–85 across four European cohorts to test the free radical/oxidative stress theory of aging. The study assessed oxidative stress using two biomarkers: derivatives of reactive oxygen metabolites (D-ROMs) as an indicator of oxidative burden and
This 2006 article by Denham Harman revisits and expands upon the Free Radical Theory of Aging (FRTA), which attributes aging to the cumulative damage caused by free radicals—especially reactive oxygen species (ROS) generated in mitochondria. The review highlights how oxidative stress contributes to cellular dysfunction, DNA and protein damage, and
