Well Referenced

Tag: folic acid

Use of Oral Supplements and Topical Adjuvants for Isotretinoin-Associated Side Effects: A Narrative Review

This 2024 narrative review evaluates the efficacy and safety of various oral supplements and topical adjuvants in mitigating mucocutaneous and musculoskeletal side effects associated with isotretinoin therapy. Oral supplements such as omega-3 fatty acids, vitamin E, folic acid with vitamin B12, antihistamines, L-carnitine, biotin, and combination supplements were found to

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June 26, 2025 No Comments

High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial

This randomized, double-blind, placebo-controlled trial assessed the efficacy of high-dose B vitamin supplementation (folic acid 5 mg, vitamin B6 25 mg, and vitamin B12 1 mg daily) in slowing cognitive decline among 409 individuals with mild to moderate Alzheimer’s disease over 18 months. Despite significant reductions in plasma homocysteine levels

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June 26, 2025 No Comments

Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial

This open-label clinical trial assessed the impact of folic acid supplementation on behavioral and biochemical parameters in children with autism spectrum disorder (ASD) undergoing structured teaching. Sixty-six children participated, with 44 receiving 400 μg of folic acid twice daily for three months, while 22 served as controls. Behavioral assessments using

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June 26, 2025 No Comments

Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care

This 2000 guideline by the Canadian Task Force on Preventive Health Care evaluates the role of hyperhomocysteinemia in coronary artery disease (CAD). Elevated total homocysteine (tHcy) levels are associated with increased CAD risk, with prevalence ranging from 5–10% in the general population and up to 30–40% in the elderly. Despite

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June 26, 2025 No Comments