fibroblasts Archives - Well Referenced

L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts

This 2004 study investigated the effects of L-carnosine, a naturally occurring dipeptide, on telomere dynamics in cultured human fetal lung fibroblasts. Cells continuously cultured with 20 mM L-carnosine exhibited a slower rate of telomere shortening and an extended replicative lifespan compared to controls. Additionally, non-dividing cells maintained in the presence

June 26, 2025 No Comments

α-Lipoic acid prevents senescence, cell cycle arrest, and inflammatory cues in fibroblasts by inhibiting oxidative stress

This 2019 in vitro study published in Pharmacological Research (DOI: 10.1016/j.phrs.2019.01.003, PMID: 30611855) investigated the protective effects of alpha-lipoic acid (ALA) on fibroblast cells exposed to oxidative stress. The results demonstrated that ALA effectively reduced oxidative stress, inhibited DNA damage, and prevented cellular senescence by modulating key redox-sensitive pathways. Specifically,

June 26, 2025 No Comments

Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts

The study titled “Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts” (Arthritis Research & Therapy, 2014, PMID: 25123250) explores the role of lipoic acid (LA) and its active metabolite, dihydrolipoic acid (DHLA), in systemic sclerosis (SSc), a disease characterized by fibrosis of the skin and

June 26, 2025 No Comments

Tag: fibroblasts

L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts

α-Lipoic acid prevents senescence, cell cycle arrest, and inflammatory cues in fibroblasts by inhibiting oxidative stress

Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts