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Tag: FGF-21

The Biochemical Assessment of Mitochondrial Respiratory Chain Disorders

This systematic review evaluates established and emerging biochemical markers for diagnosing mitochondrial respiratory chain (MRC) disorders, highlighting the potential of fibroblast growth factor-21 (FGF-21) and oxidative stress indicators. Traditional markers such as lactate and pyruvate remain important, but newer biomarkers may improve diagnostic accuracy. Challenges include a lack of standardized

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June 26, 2025 No Comments

Potential Biomarkers of Mitochondrial Dysfunction Associated with COVID-19 Infection

This systematic review explores biomarkers of mitochondrial dysfunction related to COVID-19 and long COVID. Established markers like lactate and pyruvate, along with newer indicators such as FGF-21 and oxidative stress measures (e.g., coenzyme Q10), are analyzed. The authors propose using a multiplexed metabolic profiling approach combined with spectrophotometric enzyme assays

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June 26, 2025 No Comments

Biomarkers of mitochondrial disorders

This systematic review evaluates mitochondrial biomarkers, highlighting GDF-15 and FGF-21 as the most promising candidates for diagnosing and managing mitochondrial disorders. Although these biomarkers demonstrate potential, their reliability varies across conditions, underscoring the need for further validation. Improved biomarker validation would enable earlier detection, better disease monitoring, and more precise

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June 26, 2025 No Comments