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Tag: fertility preservation

A Comparison of Secondary Polycythemia in Hypogonadal Men Treated with Clomiphene Citrate versus Testosterone Replacement: A Multi-Institutional Study

This multi-institutional retrospective study compared the prevalence of secondary polycythemia in 363 hypogonadal men treated with either clomiphene citrate (CC) or testosterone replacement therapy (TRT). The study found that polycythemia occurred in 11.2% of men receiving TRT compared to only 1.7% in the CC group (p = 0.0003). Both treatments

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June 26, 2025 No Comments

Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism

This 2019 review evaluates enclomiphene citrate, the trans-isomer of clomiphene citrate, as a treatment for secondary hypogonadism in men desiring fertility preservation. Enclomiphene acts as a selective estrogen receptor modulator (SERM), antagonizing estrogen receptors in the hypothalamus and pituitary gland, thereby stimulating the hypothalamic-pituitary-gonadal axis to increase endogenous luteinizing hormone

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June 26, 2025 No Comments

Preserving fertility in the hypogonadal patient: an update

This 2015 review addresses the challenge of managing hypogonadism in men desiring fertility preservation. Exogenous testosterone therapy can suppress the hypothalamic-pituitary-gonadal axis, leading to impaired spermatogenesis and potential azoospermia. The authors highlight alternative treatments, such as human chorionic gonadotropin (hCG), which can stimulate endogenous testosterone production and maintain intratesticular testosterone

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June 26, 2025 No Comments