Biomarkers for assessment of intestinal permeability in clinical practice
This 2021 observational study published in American Journal of Physiology-Gastrointestinal and Liver Physiology (PMID: 34009040) evaluated the correlation between the traditional lactulose/mannitol (L/M) test for intestinal permeability and surrogate biomarkers such as plasma lipopolysaccharide-binding protein (LBP) and fecal zonulin. In two cohorts—51 healthy individuals and 27 with obesity—the study found