Well Referenced

Tag: fat-free mass

Cross-calibration of Eight-Polar Bioelectrical Impedance Analysis Versus Dual-Energy X-Ray Absorptiometry for the Assessment of Total and Appendicular Body Composition in Healthy Subjects Aged 21–82 Years

This 2003 cross-sectional study assessed the validity of eight-polar bioelectrical impedance analysis (BIA) compared to dual-energy X-ray absorptiometry (DXA) in 110 healthy adults aged 21–82 years. The resistance index (RI), calculated as height² divided by resistance at 500 kHz, emerged as the strongest predictor of fat-free mass (FFM) and appendicular

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June 26, 2025 No Comments

Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure

This randomized, double-blind, placebo-controlled trial investigated the effects of the oral GH secretagogue MK-677 (25 mg daily) on GH secretion, body composition, and energy expenditure in 24 healthy obese men aged 18–50. Over 8 weeks, MK-677 significantly increased serum IGF-I levels by approximately 40% and GH secretion, as measured by

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June 26, 2025 No Comments

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial

This randomized, double-blind, placebo-controlled trial assessed the effects of the oral ghrelin mimetic MK-677 (25 mg daily) on growth hormone (GH) secretion, body composition, and clinical outcomes in 65 healthy adults aged 60–81 over 12 months. MK-677 significantly increased 24-hour mean GH and insulin-like growth factor I (IGF-I) levels to

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June 26, 2025 No Comments

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

This pooled analysis of four randomized controlled trials examined the sex-specific effects of dehydroepiandrosterone (DHEA) therapy on bone mineral density (BMD) and body composition in older adults. The study found that DHEA supplementation led to a 1.0% increase in lumbar spine BMD in women over 12 months, while men experienced

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June 26, 2025 No Comments