The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol
This 2010 study investigated the effects of ezlopitant, a selective neurokinin 1 (NK1) receptor antagonist, on the consumption and motivation for sucrose and ethanol in rodent models. Ezlopitant significantly reduced operant self-administration of 5% sucrose in a dose-dependent manner, with all tested doses (2, 5, and 10 mg/kg) decreasing intake.
June 26, 2025
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