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Tag: estrogen-only therapy

Type and Timing of Menopausal Hormone Therapy and Breast Cancer Risk: Individual Participant Meta-Analysis of the Worldwide Epidemiological Evidence

This 2019 meta-analysis by the Collaborative Group on Hormonal Factors in Breast Cancer pooled individual data from over 108,000 postmenopausal women with breast cancer and more than 400,000 without, across 58 studies worldwide, to evaluate the impact of menopausal hormone therapy (MHT) on breast cancer risk. The analysis found that

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June 26, 2025 No Comments

Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk

This cohort study evaluated the breast cancer risks associated with menopausal hormone replacement therapy (HRT) in postmenopausal women, comparing estrogen-only therapy to estrogen-progestin therapy. The study found that both estrogen-only and estrogen-progestin therapies increased breast cancer risk, with estrogen-progestin therapy showing a higher risk, particularly in women with lower BMI.

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June 26, 2025 No Comments

Postmenopausal hormone therapy and risk of breast cancer

This review examines the relationship between postmenopausal hormone therapy (HT) and breast cancer risk, analyzing data from various studies. Findings suggest that combined estrogen-progestogen therapy is associated with a higher risk of breast cancer than estrogen-only therapy, with risk increasing with duration of use and decreasing after discontinuation. The type

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June 26, 2025 No Comments