Well Referenced

Tag: estradiol

Effects of subdermal implants of estradiol and testosterone on the endometrium of postmenopausal women

This 2007 retrospective study evaluated the endometrial effects of combined estradiol and testosterone subdermal implants in 258 postmenopausal women over two years. Endometrial thickness was monitored via ultrasonography, and hysteroscopic biopsies were performed in cases of thickening (>5 mm). Among 44 women with endometrial thickening, histological analysis revealed endometrial polyps

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June 26, 2025 No Comments

Hormonal therapy with estradiol and testosterone implants: bone protection?

This 2011 prospective cohort study assessed the impact of combined estradiol and testosterone implants on bone mineral density (BMD) in postmenopausal women. Sixty-one participants were divided into two groups: 34 women received hormone implants, while 27 did not undergo hormonal therapy. Over one year, the implant group maintained or slightly

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June 26, 2025 No Comments

Estradiol implants for conception control

This 1980 study evaluated the contraceptive efficacy of subcutaneous 17β-estradiol pellet implants in women over 35 years old who could not tolerate oral contraceptives. The regimen involved descending doses (25 mg pellets) implanted at six-month intervals. Over 18,480 cycles (1,540 woman-years), the corrected Pearl Index was 0.273, indicating high contraceptive

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June 26, 2025 No Comments

Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men

This randomized, double-blind, placebo-controlled trial investigated the distinct roles of testosterone and estradiol in regulating body composition, muscle strength, and sexual function in men. Healthy men aged 20–50 underwent pharmacological suppression of endogenous gonadal steroids and received varying doses of testosterone gel, with or without an aromatase inhibitor to block

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June 26, 2025 No Comments

Effect of Lepidium meyenii (MACA) on Sexual Desire and Its Absent Relationship with Serum Testosterone Levels in Adult Healthy Men

This 12-week double-blind, placebo-controlled, randomized trial investigated the effects of gelatinized maca (Lepidium meyenii) on sexual desire and hormone levels in 57 healthy men aged 21–56. Participants received either 1,500 mg or 3,000 mg of maca daily or a placebo. Self-perception of sexual desire was assessed at 4, 8, and

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June 26, 2025 No Comments

Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study

This double-blind, randomized, placebo-controlled study evaluated the effects of a standardized Trigonella foenum-graecum (fenugreek) seed extract (Libifem) on sex hormones and sexual function in 80 healthy menstruating women aged 20–49 years with self-reported low sexual desire. Participants received 600 mg/day of Libifem or placebo over two menstrual cycles. Outcomes included

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June 26, 2025 No Comments

Pharmacokinetic evaluation and dosing of subcutaneous testosterone pellets

This 2012 retrospective study analyzed 273 hypogonadal men treated with subcutaneous testosterone pellets to determine optimal dosing and reimplantation schedules. The study found that men receiving 10–12 pellets achieved higher peak total and free testosterone levels compared to those receiving 6–9 pellets, although decay rates were similar. Elevated estradiol levels

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June 26, 2025 No Comments

Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer’s Disease Mouse Model

This study investigates the effects of methylene blue (MB) in a mouse model of Alzheimer’s disease (AD) induced by neuroinflammation. The study found that MB treatment reduced amyloid beta (Aβ) oligomers, decreased oxidative stress, and improved mitochondrial function by inhibiting the mitochondrial enzyme ABAD. Additionally, MB treatment restored brain estradiol

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June 26, 2025 No Comments

The menopause and sexual functioning: a review of the population-based studies

This systematic review examines population-based studies assessing the impact of menopause on women’s sexual functioning, distinguishing between age-related and menopause-specific declines. Findings indicate that sexual dysfunction increases with menopausal transition, as seen in the Melbourne Women’s Midlife Health Project, where rates rose from 42% in early menopause to 88% in

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June 26, 2025 No Comments

The role of androgens and estrogens on healthy aging and longevity

This review examines the role of androgens and estrogens in aging, focusing on their impact on muscle mass, bone density, and overall physical function. In men, declining testosterone levels are linked to reduced muscle mass, bone density, and strength, while in women, estradiol deficiency primarily affects bone health, with less

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June 26, 2025 No Comments