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Tag: eosinophils

Clinical Trial of Human Umbilical Cord Blood-Derived Stem Cells for the Treatment of Moderate-to-Severe Atopic Dermatitis: Phase I/IIa Studies

This Phase I/IIa clinical trial evaluated the safety and efficacy of subcutaneous injections of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in 34 adult patients with moderate-to-severe atopic dermatitis (AD). Participants were randomized to receive either a low dose (2.5 × 10⁷ cells) or a high dose (5.0 ×

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June 26, 2025 No Comments

Vitamin A and D in allergy: from experimental animal models and cellular studies to human disease

This 2018 review explores the immunomodulatory roles of vitamins A and D in allergic diseases. Animal studies indicate that deficiencies in these vitamins exacerbate allergic symptoms and lung inflammation, while supplementation, particularly with vitamin D, can attenuate these effects. Active metabolites—retinoic acid (RA) from vitamin A and 1,25-dihydroxyvitamin D3 (VD3)

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June 26, 2025 No Comments

In vitro and in vivo Antiallergic Effects of Taurine on Allergic Rhinitis

This 2020 study investigated taurine’s antiallergic effects on allergic rhinitis (AR) through both in vitro and in vivo models. In AR patients, serum levels of extracellular superoxide dismutase (SOD3) were reduced. Taurine treatment increased SOD3 expression in human mast cells via activation of peroxisome proliferator-activated receptor-γ (PPAR-γ), leading to decreased

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June 26, 2025 No Comments