This 2022 narrative review explores the phenomenon of acquired G6PD deficiency, a condition where G6PD enzyme activity is reduced due to non-genetic factors. Unlike the hereditary form, acquired G6PD deficiency arises from biochemical mechanisms that inhibit the enzyme in specific clinical contexts. The review identifies conditions such as hyperaldosteronism, diabetes,
This review investigates the neuroprotective effects of six phytomedicines—Panax ginseng, Ginkgo biloba, Bacopa monnieri, Withania somnifera, Curcuma longa, and Lavandula angustifolia—against Alzheimer’s disease (AD). The study highlights how these plants and their active components can help reverse neurological changes in AD, such as amyloid-beta plaques and neurofibrillary tangles, and improve
This in vitro study examined the toxic effects of malonaldehyde (MDA), a product of lipid peroxidation, on mitochondrial function in isolated rat liver mitochondria. MDA exposure resulted in a dose-dependent decrease in oxygen consumption, indicating impaired mitochondrial respiratory function. The study also observed the inhibition of key mitochondrial enzymes, including
This in vitro study investigated the effects of malondialdehyde (MDA), a byproduct of lipid peroxidation, on mitochondrial function in rat brain mitochondria. MDA exposure led to a dose-dependent reduction in mitochondrial membrane potential, inhibited complex I- and II-linked respiration, and suppressed the activity of key enzymes like NADH dehydrogenase, succinate
This in vitro study examined the inhibitory effects of five structural analogues of methylene blue (MB)—neutral red, Nile blue, new methylene blue, cresyl violet, and 1,9-dimethyl methylene blue—on human monoamine oxidase (MAO) enzymes. The results demonstrated that all analogues selectively inhibited the MAO-A isoform, with cresyl violet (IC₅₀ = 0.0037
