Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function
This cohort study examined how genetic variations in glutathione S-transferase (GST) enzymes—specifically the GSTP1 Val105 and GSTM1 deletion polymorphisms—modify the relationship between cumulative lead exposure and cognitive function in older men from the Normative Aging Study. Using bone lead levels measured by K-shell X-ray fluorescence and Mini-Mental State Exam (MMSE)