This article examines the hypothesis that most cancers arise due to specific risk factors acting on tissues with high underlying stem cell divisions. It discusses the role of stem cells in tissue renewal and how mutations during stem cell division may contribute to cancer development. The review also explores various
This review article explores how environmental and biological factors—such as pollution, poor nutrition, oxidative stress, and psychosocial stress—contribute to “inflammaging,” a chronic low-grade inflammatory state associated with aging. While genetic predisposition plays a minor role, the authors highlight that environmental exposures are key drivers of age-related inflammation and chronic diseases.
This 2022 review published in Digestive Diseases and Sciences (PMID: 34981314) explores how environmental factors, such as food additives and contaminants (including pesticides and microplastics), contribute to chronic low-grade inflammation in the gastrointestinal (GI) tract. These factors disrupt gut microbiota, compromise the intestinal barrier, and promote systemic inflammation, leading to
