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Tag: endoplasmic reticulum stress

Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer’s disease: endoplasmic reticulum stress and immunological stress in pathogenesis of Alzheimer’s disease

This review explores the roles of endoplasmic reticulum (ER) stress and immunological stress in Alzheimer’s disease (AD) pathogenesis. ER stress, resulting from the accumulation of misfolded proteins, activates the unfolded protein response (UPR), which aims to restore protein homeostasis but can lead to apoptosis if prolonged. Key UPR pathways involve

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June 26, 2025 No Comments

The Challenge by Multiple Environmental and Biological Factors Induce Inflammation in Aging: Their Role in the Promotion of Chronic Disease

This review article explores how environmental and biological factors—such as pollution, poor nutrition, oxidative stress, and psychosocial stress—contribute to “inflammaging,” a chronic low-grade inflammatory state associated with aging. While genetic predisposition plays a minor role, the authors highlight that environmental exposures are key drivers of age-related inflammation and chronic diseases.

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June 26, 2025 No Comments