This 2010 review examines the influence of metabolic and endocrine factors on mild cognitive impairment (MCI). It highlights chronic kidney disease as a newly identified independent risk factor for MCI. The review discusses the potential benefits of testosterone substitution in individuals with low testosterone levels, though routine screening is not
The article “The Association of Hypogonadism with Depression and Its Treatments” explores the bidirectional relationship between male hypogonadism and depression. Men with hypogonadism often experience depressive symptoms, anxiety, insomnia, and cognitive impairment, which may improve with testosterone replacement therapy (TRT). However, the prevalence of hypogonadism in depressed individuals and the
The study titled “Assessment of adverse reactions to α-lipoic acid containing dietary supplements through spontaneous reporting systems” (Clinical Nutrition, 2021, PMID: 32778460) is an observational study analyzing 116 reports of adverse reactions (ARs) to α-lipoic acid (ALA) supplements collected by the Italian Phytovigilance System from 2002 to 2020. The majority
