Well Referenced

Tag: elderly

Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline

This 2024 guideline updates the 2011 recommendations, focusing on vitamin D use for disease prevention in individuals without established indications for treatment or 25(OH)D testing. Key recommendations include: (1) Empiric vitamin D supplementation is suggested for children and adolescents aged 1–18 years to prevent nutritional rickets and potentially reduce respiratory

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June 26, 2025 No Comments

Atrial Fibrillation: A Geriatric Perspective on the 2020 ESC Guidelines

This review provides a geriatric lens on the 2020 European Society of Cardiology (ESC) guidelines for atrial fibrillation (AF), emphasizing the need for individualized care in older adults. While the ESC promotes an “ABC” approach—Anticoagulation/Avoid stroke, Better symptom control, and Cardiovascular risk and comorbidity management—the authors argue that this framework

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June 26, 2025 No Comments

Supplemental thiamine as a practical, potential way to prevent Alzheimer’s disease from commencing

This article proposes that thiamine (vitamin B1) supplementation may serve as a preventive strategy against Alzheimer’s disease (AD) in elderly individuals who are cognitively normal but exhibit amyloid or tau deposition. Thiamine deficiency is common in older adults and is associated with several AD-related pathologies, including synaptic hypometabolism, mitochondrial dysfunction,

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June 26, 2025 No Comments

Comparison of the Clinical Efficacy of Daily Use of L-arginine, Tadalafil, and Combined L-arginine with Tadalafil in the Treatment of Elderly Patients with Erectile Dysfunction

This 2020 single-blind, placebo-controlled clinical trial assessed the efficacy of daily oral administration of L-arginine (5 g), tadalafil (5 mg), and their combination in 120 men aged ≥60 years with erectile dysfunction (ED). Participants were randomized into four groups (n=30 each) receiving L-arginine, tadalafil, combined therapy, or placebo for 6

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June 26, 2025 No Comments

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial

This randomized, double-blind, placebo-controlled trial assessed the effects of the oral ghrelin mimetic MK-677 (25 mg daily) on growth hormone (GH) secretion, body composition, and clinical outcomes in 65 healthy adults aged 60–81 over 12 months. MK-677 significantly increased 24-hour mean GH and insulin-like growth factor I (IGF-I) levels to

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June 26, 2025 No Comments

Stimulation of the Growth Hormone (GH)-Insulin-Like Growth Factor I Axis by Daily Oral Administration of a GH Secretagogue (MK-677) in Healthy Elderly Subjects

This 1996 randomized, double-blind, placebo-controlled study by Chapman et al. investigated the effects of MK-677, an orally active growth hormone secretagogue, on the GH/IGF-I axis in healthy elderly individuals aged 64–81. Participants received daily doses of 2, 10, or 25 mg of MK-677 or placebo over two treatment periods (14

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June 26, 2025 No Comments

TORC1 Inhibition Enhances Immune Function and Reduces Infections in the Elderly

This 2018 phase 2a randomized, placebo-controlled clinical trial evaluated the effects of selective TORC1 inhibition on immune function in 264 elderly participants. The study administered a low-dose combination of BEZ235 (a catalytic mTOR inhibitor) and RAD001 (everolimus, an allosteric mTOR inhibitor) for 6 weeks. Results showed a significant reduction in

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June 26, 2025 No Comments

Association of Dietary Magnesium Intake With Leukocyte Telomere Length in United States Middle-Aged and Elderly Adults

This 2022 observational study used data from 4,039 U.S. adults aged 45 and older (NHANES 1999–2002) to explore the relationship between dietary magnesium intake and leukocyte telomere length (LTL), a biomarker of cellular aging. Researchers found that higher magnesium intake was significantly associated with longer LTL, with participants consuming ≥299

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June 26, 2025 No Comments