Well Referenced

Tag: Elderly Patients

Adding ascorbic acid to arsenic trioxide produces limited benefit in patients with acute myeloid leukemia excluding acute promyelocytic leukemia

This phase II clinical trial evaluated the efficacy and safety of combining arsenic trioxide (ATO) with ascorbic acid (AA) in patients with acute myeloid leukemia (AML) excluding acute promyelocytic leukemia (APL). Eleven patients, including elderly individuals unfit for intensive chemotherapy, received intravenous ATO (0.25 mg/kg/day) and AA (1 g/day) for

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June 26, 2025 No Comments

Perioperative Covert Stroke in Patients Undergoing Non-Cardiac Surgery (NeuroVISION): A Prospective Cohort Study

The NeuroVISION study, a multicenter prospective cohort study, investigated the incidence and impact of covert strokes—acute brain infarcts detected by MRI without clinical symptoms—in patients aged 65 and older undergoing non-cardiac surgery. Among 1,114 participants, 7% experienced a covert stroke postoperatively. These events were associated with a twofold increase in

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June 26, 2025 No Comments

Updated recommendations of the International Society of Geriatric Oncology on prostate cancer management in older patients

This 2019 consensus by the International Society of Geriatric Oncology (SIOG) emphasizes that prostate cancer management in men aged 75 years and older should be based on individual health status rather than chronological age. The recommendations advocate for comprehensive geriatric assessments to evaluate comorbidities, functional status, and life expectancy, guiding

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June 26, 2025 No Comments

Oxygen-ozone therapy for degenerative spine disease in the elderly: a prospective study

This prospective observational study evaluated the efficacy of oxygen-ozone therapy in elderly patients with degenerative spine disease. Administered as a minimally invasive intervention, oxygen-ozone therapy led to significant improvements in pain relief and mobility with no reported adverse effects, highlighting its potential as an alternative to invasive procedures. The study

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June 26, 2025 No Comments

Efficacy and Safety of Oral Magnesium Supplementation in the Treatment of Depression in the Elderly With Type 2 Diabetes: A Randomized, Equivalent Trial

This 2008 randomized controlled trial evaluated the effectiveness of oral magnesium supplementation versus imipramine in treating depression among elderly patients with type 2 diabetes. The study found that magnesium was equally effective as imipramine in improving depression scores, while offering a more favorable side effect profile. Magnesium’s role in neurotransmitter

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June 26, 2025 No Comments

Randomized Clinical Trial of How Long-Term Glutathione Supplementation Offers Protection from Oxidative Damage and Improves HbA1c in Elderly Type 2 Diabetic Patients

This randomized controlled trial evaluated the effects of long-term oral glutathione (GSH) supplementation on oxidative stress and glycemic control in 250 type 2 diabetic (T2D) patients compared to 104 healthy controls. Over six months, participants receiving 500 mg of daily GSH experienced significantly increased blood GSH levels and reduced oxidative

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June 26, 2025 No Comments

Management of localised prostate cancer: watchful waiting, surgery or radiation therapy, depending on the natural course, which is often relatively slow

This review article examines the management of localized prostate cancer, highlighting watchful waiting, radical prostatectomy, and radiation therapy as primary treatment options. It emphasizes that prostate cancer often progresses slowly, particularly in men over 65, making active surveillance a viable option for many patients. The choice of treatment should be

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June 26, 2025 No Comments

Improvement of pain and disability in elderly patients with degenerative osteoarthritis of the knee treated with narrow-band light therapy

This randomized controlled trial evaluated the efficacy of low-power narrow-band light therapy in reducing pain and disability among elderly patients with degenerative osteoarthritis of the knee. Fifty participants were assigned to red light, infrared light, or placebo treatments, self-administering therapy for 15 minutes twice daily over 10 days. Both active

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June 26, 2025 No Comments