Well Referenced

Tag: drug resistance

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease

This article explores the potential of antibiotics that target mitochondrial function in eradicating cancer stem cells across various tumor types. The study suggests that by targeting mitochondria, these antibiotics disrupt key cellular processes in cancer stem cells, effectively reducing tumor recurrence and resistance to conventional therapies. The review proposes a

Read More »
June 26, 2025 No Comments

Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stress and non-caspase apoptosis

This study examines how artesunate overcomes drug resistance in multiple myeloma cells by inducing mitochondrial stress and non-caspase-dependent apoptosis. The findings suggest that artesunate disrupts mitochondrial function, leading to cell death independent of the traditional caspase pathway. These results highlight artesunate as a potential therapeutic agent to bypass common mechanisms

Read More »
June 26, 2025 No Comments

Glutathione in cancer biology and therapy

The article “Glutathione in Cancer Biology and Therapy” examines the multifaceted role of glutathione (GSH) in cancer, emphasizing its impact on cell growth, DNA synthesis, mutagenic processes, and resistance to chemotherapy and radiation. Elevated levels of GSH in many tumors contribute to drug resistance and survival during oxidative and nitrosative

Read More »
June 26, 2025 No Comments

The role of glutathione in cancer

This systematic review explores the dual roles of glutathione in cancer biology, where it acts as both a protective antioxidant and a factor contributing to chemotherapy resistance in tumor cells. Elevated glutathione levels in cancer cells enable them to neutralize chemotherapeutic agents, reducing drug efficacy and complicating cancer treatment. By

Read More »
June 26, 2025 No Comments

The effects of Provera on chemotherapy of uterine cancer cell lines

A study examined the effects of Provera, a progestational compound, on the efficacy of chemotherapy in various uterine cancer cell lines. Using the ATP chemosensitivity assay and flow cytometry, researchers analyzed progesterone-receptor (PR)-positive (AE7 and ECC1) and PR-negative (HEC1A, HEC1B, AN3, and SKUT1B) cell lines. The findings showed that Provera

Read More »
June 26, 2025 No Comments