Well Referenced

Tag: drug interaction

Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models

This 2011 study by Chen et al. investigates the anti-cancer effects of high-dose intravenous ascorbic acid (AA) and its interaction with intravenous glutathione (GSH) in preclinical cancer models. The research demonstrates that pharmacologic concentrations of AA induce cytotoxicity in various cancer cell lines through the generation of hydrogen peroxide (H₂O₂),

Read More »
June 26, 2025 No Comments

An easily overlooked cause of toxic encephalopathy: methylene blue in a patient on an SSRI

This case report highlights a serious drug interaction between methylene blue (MB) and selective serotonin reuptake inhibitors (SSRIs), leading to toxic encephalopathy and serotonin syndrome. A patient on sertraline underwent surgery where MB was administered, resulting in postoperative neurological symptoms, including altered mental status. MB inhibits monoamine oxidase A (MAO-A),

Read More »
June 26, 2025 No Comments