This review explores the use of mannitol, an osmotic agent, to transiently disrupt the blood-brain barrier (BBB) and facilitate the delivery of stem cells and their associated growth factors into the central nervous system. The authors discuss preclinical studies demonstrating that mannitol-induced BBB opening enhances the entry of various stem
This 2018 review examines the complex role of nitric oxide (NO) in cancer biology, particularly in prostate and bladder cancers. While low levels of NO can support tumor progression through angiogenesis and immune evasion, high concentrations can trigger apoptosis and sensitize tumors to chemotherapy and radiotherapy. The paper evaluates various
In this 2018 review published in Brain Research Bulletin, Erdő et al. critically examine the intranasal route as a non-invasive method for delivering therapeutic agents directly to the brain, effectively bypassing the blood-brain barrier (BBB). The authors discuss the anatomical and physiological features of the nasal cavity that facilitate drug
This study explores the therapeutic potential of cannabidiol (CBD) for brain disorders, focusing on its interaction with multiple brain targets and evaluating alternative drug delivery methods to enhance its efficacy. Oral CBD administration is limited by slow absorption and low bioavailability due to first-pass metabolism, prompting interest in alternative delivery
This study explores the use of methylene blue (MB)-loaded nanoparticles for treating Alzheimer’s disease (AD) and other tauopathies. The nanoparticles, designed to improve MB’s bioavailability in the brain, are formulated using PLGA-b-PEG and are 136.5 nm in size. They exhibit a sustained drug release profile, effectively reducing tau protein levels
