This 2018 review published in Subcellular Biochemistry (PMID: 30779015) explores the evolving relationship between gut microbiota and aging, synthesizing research from model organisms such as Drosophila melanogaster, killifish, mice, and Caenorhabditis elegans. It highlights how age-associated changes in gut microbial composition may not only reflect aging but actively contribute to
This 2015 observational study published in Cell Reports (PMID: 26321641) examined how aging in Drosophila melanogaster (fruit flies) affects gut microbiota and intestinal barrier function. Researchers found that aging flies experienced a notable shift in gut microbiota composition, particularly an expansion of Gammaproteobacteria, which preceded and predicted intestinal barrier dysfunction.
This 2018 review published in Cellular and Molecular Life Sciences (PMID: 29026921) examines how age-related changes in gut microbiota contribute to health decline, drawing from studies in invertebrate models like Drosophila melanogaster and Caenorhabditis elegans. The review highlights how dysbiosis during aging disrupts intestinal homeostasis, increases gut permeability, triggers immune
