DL- and PO-phosphatidylcholines as a promising learning and memory enhancer
This study evaluates the cognitive-enhancing effects of two phosphatidylcholine derivatives: 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPhtCho) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPhtCho). In scopolamine-induced amnesic rats, oral administration of DLPhtCho (5 mg/kg) or POPhtCho (5 mg/kg) individually, and especially their combination, significantly reduced acquisition and retention latencies in the Morris water maze test. The combined treatment outperformed
June 26, 2025
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