Well Referenced

Tag: dietary interventions

Redox Biomarkers in Dietary Interventions and Nutritional Observation Studies – From New Insights to Old Problems

This comprehensive review evaluates the use of redox biomarkers in dietary intervention and observational studies. Analyzing 88 studies, it highlights the inconsistent application of biomarkers across three categories: oxidative damage, endogenous antioxidants, and exogenous antioxidants. Only a minority of studies assessed all three, often relying on limited or controversial assays

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June 26, 2025 No Comments

A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension

This review examines the role of methionine dependency in cancer cells and the potential benefits of methionine restriction in cancer growth control and life-span extension. The review highlights that cancers exhibiting methionine dependence can be targeted by reducing methionine availability, either through dietary changes (e.g., vegan diets) or methionine-depleting therapies

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June 26, 2025 No Comments

Drivers of age-related inflammation and strategies for healthspan extension

This review discusses the role of chronic inflammation driven by the NLRP3 inflammasome in age-related conditions such as arthritis, diabetes, cardiovascular disease, and Alzheimer’s disease. It highlights how the accumulation of damage-associated molecular patterns (DAMPs) with age activates NLRP3, increasing IL-1β and IL-18 production and contributing to systemic inflammation. The

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June 26, 2025 No Comments

Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application

The 2015 article “Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application” (Journal of Nutrition and Metabolism, PMID: 26167297) reviews how various foods and nutrients influence the body’s detoxification systems, particularly phase I cytochrome P450 enzymes, phase II conjugation enzymes, Nrf2 signaling, and

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June 26, 2025 No Comments

Impact of Supplementary Amino Acids, Micronutrients, and Overall Diet on Glutathione Homeostasis

This systematic review evaluates how supplementation with glutathione (GSH) precursor amino acids—particularly cysteine, glycine, and glutamate—as well as non-precursor amino acids, micronutrients (such as vitamins C and E), and overall dietary patterns influence glutathione homeostasis and antioxidant defense. Because orally consumed GSH is inefficiently absorbed due to intestinal degradation, enhancing

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June 26, 2025 No Comments

Leaky gut: mechanisms, measurement and clinical implications in humans

This 2019 review article published in Gut (PMID: 31076401) explores the mechanisms, measurement, and clinical implications of intestinal permeability (“leaky gut”) in humans. It outlines the structure of the intestinal barrier—comprising mucus, epithelial cells, and immune defenses—and describes how disruptions from stress, NSAIDs, extreme exercise, pregnancy, bile acids, and food

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June 26, 2025 No Comments

Clinical review: The benefits and harms of systemic testosterone therapy in postmenopausal women with normal adrenal function: a systematic review and meta-analysis

This article discusses a study on the impacts of a dietary intervention that included supplements and lifestyle changes to improve metabolic health. It highlights benefits such as better blood sugar control and weight loss in patients with insulin resistance. The study found significant improvements, with subjects showing a marked decrease

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June 26, 2025 No Comments

Th9 cells in allergic diseases: A role for the microbiota?

This review explores the role of T helper 9 (Th9) cells in allergic diseases and how the microbiota influences Th9 activity. Certain microbes, such as Staphylococcus aureus and Candida albicans, can stimulate Th9 responses, exacerbating allergic inflammation, while microbial and dietary metabolites like retinoic acid, butyrate, and vitamin D may

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June 26, 2025 No Comments