Well Referenced

Tag: diastolic dysfunction

Effect of L-Arginine on Cardiac Reverse Remodeling and Quality of Life in Patients with Heart Failure

This 2021 double-blind randomized controlled trial investigated the effects of L-arginine supplementation in 50 patients with ischemic heart failure. Participants received either 3 grams per day of L-arginine or a placebo for 10 weeks. The study assessed cardiac function through echocardiography and six-minute walk tests, and quality of life using

June 26, 2025 No Comments

NAD⁺ Repletion Reverses Heart Failure With Preserved Ejection Fraction

This 2021 study demonstrates that NAD⁺ repletion can reverse heart failure with preserved ejection fraction (HFpEF) in a mouse model. Researchers found that HFpEF is associated with reduced myocardial NAD⁺ levels, leading to mitochondrial protein hyperacetylation and impaired fatty acid oxidation. Supplementation with NAD⁺ precursors, such as nicotinamide riboside (NR)

June 26, 2025 No Comments