Well Referenced

Tag: diagnostic tools

Biomarkers of mitochondrial disorders

This systematic review evaluates mitochondrial biomarkers, highlighting GDF-15 and FGF-21 as the most promising candidates for diagnosing and managing mitochondrial disorders. Although these biomarkers demonstrate potential, their reliability varies across conditions, underscoring the need for further validation. Improved biomarker validation would enable earlier detection, better disease monitoring, and more precise

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June 26, 2025 No Comments

Laboratory testing for mitochondrial diseases: biomarkers for diagnosis and follow-up

This systematic review examines the strengths and limitations of current biomarkers used in diagnosing and monitoring mitochondrial diseases (MDs), emphasizing the need for more specific, reliable markers. While traditional markers like lactate and organic acids remain widely used, newer options like circulating cell-free mitochondrial DNA show promise but require further

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June 26, 2025 No Comments

The Biochemical Assessment of Mitochondrial Respiratory Chain Disorders

This systematic review evaluates established and emerging biochemical markers for diagnosing mitochondrial respiratory chain (MRC) disorders, highlighting the potential of fibroblast growth factor-21 (FGF-21) and oxidative stress indicators. Traditional markers such as lactate and pyruvate remain important, but newer biomarkers may improve diagnostic accuracy. Challenges include a lack of standardized

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June 26, 2025 No Comments

Potential Biomarkers of Mitochondrial Dysfunction Associated with COVID-19 Infection

This systematic review explores biomarkers of mitochondrial dysfunction related to COVID-19 and long COVID. Established markers like lactate and pyruvate, along with newer indicators such as FGF-21 and oxidative stress measures (e.g., coenzyme Q10), are analyzed. The authors propose using a multiplexed metabolic profiling approach combined with spectrophotometric enzyme assays

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June 26, 2025 No Comments

Assessment of mitochondrial respiratory chain enzymes in cells and tissues

This review outlines standardized methodologies for assessing mitochondrial respiratory chain enzyme activity, highlighting their diagnostic utility for mitochondrial diseases. By offering consistent protocols and detailing enzymatic assays, the article supports their integration into both clinical and research settings. This enables precise identification of oxidative phosphorylation deficits, improving diagnostic accuracy and

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June 26, 2025 No Comments

Arriving at the diagnosis of female sexual dysfunction

This article explores the diagnosis of female sexual dysfunction (FSD), focusing on the revised definitions in the DSM-5 and the importance of assessing personal distress. It emphasizes the use of structured diagnostic tools, such as questionnaires, to evaluate FSD in clinical settings. The review underscores that sexual dysfunction should be

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June 26, 2025 No Comments