This 2022 systematic review by Wen et al. evaluated the efficacy and safety of ozone therapy in treating chronic wounds, including diabetic foot ulcers (DFUs). The analysis included 12 randomized controlled trials utilizing various ozone delivery methods such as topical applications (ozone gas baths, ozonated oil, ozone water flushing) and
This cohort study evaluated the effectiveness of comprehensive ozone therapy for healing diabetic foot ulcers (DFUs) in 200 patients aged 18-85. The ozone therapy group, which received ozone treatment alongside standard care, showed significantly faster wound healing, with complete wound closure in all patients within an average of 69.44 days.
This systematic review published in Medical Gas Research (2020) analyzes 28 studies evaluating the efficacy of ozonated oil in treating various acute and chronic inflammatory skin conditions, such as burns, diabetic foot ulcers, and aphthous ulcers. The key findings show that ozonated oil exhibits strong antimicrobial, anti-inflammatory, and regenerative effects
This systematic review investigates the effectiveness of hyperbaric oxygen therapy (HBOT) in treating chronic, non-healing wounds, such as diabetic foot ulcers. The analysis revealed that HBOT significantly improves wound healing, with studies showing a 30%-50% improvement in healing rates and enhanced tissue oxygenation. The treatment promotes tissue regeneration through increased
This meta-analysis examined the effectiveness of hyperbaric oxygen therapy (HBOT) as an adjunctive treatment for chronic lower limb ulcers, particularly diabetic foot ulcers. The review included twelve randomized controlled trials with 577 participants and found that HBOT significantly increased ulcer healing rates at six weeks compared to standard care (risk
