Well Referenced

Tag: Diabetic Complications

Pluripotent protective effects of carnosine, a naturally occurring dipeptide

This review article explores the multifaceted protective effects of carnosine, a naturally occurring dipeptide found abundantly in the brain, muscles, and lens. It highlights carnosine’s antioxidant capabilities, its ability to scavenge reactive oxygen species and aldehydes, and its inhibition of protein glycation and DNA-protein cross-linking, which collectively prevent cellular damage.

Read More »
June 26, 2025 No Comments

Therapeutic potential of benfotiamine and its molecular targets

This review article explores the therapeutic potential of benfotiamine, a lipid-soluble derivative of thiamine (vitamin B1), highlighting its superior bioavailability and its ability to activate transketolase—an enzyme that diverts harmful glycolytic intermediates from pathways that lead to advanced glycation end products (AGEs), a key factor in diabetic vascular complications. Benfotiamine

Read More »
June 26, 2025 No Comments

Carnosine protects proteins against methylglyoxal-mediated modifications

This in vitro study explores the potential of carnosine, a naturally occurring dipeptide, in protecting proteins from methylglyoxal (MG)-induced modifications, which are associated with the formation of advanced glycation end-products (AGEs) and diabetic complications. The research demonstrates that carnosine effectively inhibits MG-induced protein modifications and prevents AGE formation, suggesting it

Read More »
June 26, 2025 No Comments

Limb Preservation Using Edetate Disodium-based Chelation in Patients with Diabetes and Critical Limb Ischemia: An Open-label Pilot Study

The open-label pilot study titled “Limb Preservation Using Edetate Disodium-based Chelation in Patients with Diabetes and Critical Limb Ischemia” evaluated the safety and efficacy of edetate disodium-based infusions in 10 diabetic patients with critical limb ischemia (CLI). Participants received up to 50 infusions, with assessments for safety, clinical efficacy, metal

Read More »
June 26, 2025 No Comments