This 2016 prospective cohort study analyzed data from 73,679 German individuals aged 75 and older, free of dementia at baseline, to investigate the association between proton pump inhibitor (PPI) use and incident dementia. Regular PPI use (defined as at least one prescription per quarter over 18 months) was associated with
This prospective cohort study analyzed data from 3,434 participants aged 65 and older without dementia at baseline, enrolled in the Adult Changes in Thought (ACT) study, to examine the association between cumulative use of strong anticholinergic medications and the risk of incident dementia. Over a mean follow-up of 7.3 years,
This cohort study examined the association between dietary choline intake, particularly phosphatidylcholine, and dementia risk in 2,497 middle-aged and older men in eastern Finland over a 21.9-year follow-up. Men in the highest quartile of phosphatidylcholine intake had a 28% lower risk of developing dementia compared to those in the lowest
