Well Referenced

Tag: dehydroascorbic acid

ONCOLOGY. Vitamin C could target some common cancers

This 2015 news article in Science discusses findings from a study by Yun et al., which demonstrated that high-dose vitamin C selectively kills colorectal cancer cells harboring KRAS or BRAF mutations. The mechanism involves vitamin C entering cancer cells as dehydroascorbic acid (DHA) via GLUT1 transporters. Inside the cell, DHA

Read More »
June 26, 2025 No Comments

Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy

This hypothesis article posits that aggressive cancers often exhibit reduced expression or activity of the SVCT2 transporter, leading to suboptimal intracellular ascorbate levels. This deficiency may result in elevated activity of hypoxia-inducible factor-1 (HIF-1), promoting tumor aggressiveness. The acidic microenvironment of tumors further impairs SVCT2 function. The author suggests that

Read More »
June 26, 2025 No Comments